tert-Butyl 2,8-diazaspiro(4.5)decane-8-carboxylate → tert-Butyl-2-[4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)benzoyl]-2,8-diazaspiro[4.5]decane-8-carboxylate

HRID 2093652Notes

Reaction equation

HRID 2093652 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([CH:21]([CH3:23])[CH3:22])[C:6]2[O:10][C:9]([C:11]3[CH:19]=[CH:18][C:14]([C:15](O)=[O:16])=[CH:13][CH:12]=3)=[N:8][C:7]=2[CH:20]=1)#[N:2].[CH2:24]1[C:28]2([CH2:33][CH2:32][N:31]([C:34]([O:36][C:37]([CH3:40])([CH3:39])[CH3:38])=[O:35])[CH2:30][CH2:29]2)[CH2:27][CH2:26][NH:25]1>>[C:37]([O:36][C:34]([N:31]1[CH2:32][CH2:33][C:28]2([CH2:24][N:25]([C:15](=[O:16])[C:14]3[CH:13]=[CH:12][C:11]([C:9]4[O:10][C:6]5[C:5]([CH:21]([CH3:23])[CH3:22])=[CH:4][C:3]([C:1]#[N:2])=[CH:20][C:7]=5[N:8]=4)=[CH:19][CH:18]=3)[CH2:26][CH2:27]2)[CH2:29][CH2:30]1)=[O:35])([CH3:40])([CH3:39])[CH3:38]

Participants

3

Reactant 2

HCID 23282900tert-Butyl 2,8-diazaspiro(4.5)decane-8-carboxylateHCID 573699454-(5-Cyano-7-isopropylbenzo[d]oxazol-2-yl)benzoic acid2×

Product 1

HCID 68745807tert-Butyl-2-[4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)benzoyl]-2,8-diazaspiro[4.5]decane-8-carboxylate

Procedure

The title compound was synthesized from 4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)benzoic acid (INTERMEDIATE 2) and tert-butyl 2,8-diazaspiro[4.5]decane-8-carboxylate following the procedure described in EXAMPLE 120. Mass spectrum (ESI) 529.2 (M+1).

Sources & evidence

ORD record
ord-b79e44af0a6e49d0902f8cb5699cd945
Source dataset
uspto-grants-2013_05
Patent number
US08445480B2

Reaction notes

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