(R)-Methyl 2-((2-chloro-5-nitropyrimidin-4-yl)(cyclopentyl)amino)butanoate → (R)-methyl 2-((2-chloro-5-nitropyrimidin-4-yl)(isopropyl)amino)butanoate

HRID 2093661Notes

Reaction equation

HRID 2093661 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([N:8]([CH:16]2[CH2:20]CC[CH2:17]2)[C@H:9]([CH2:14][CH3:15])[C:10]([O:12][CH3:13])=[O:11])[C:5]([N+:21]([O-:23])=[O:22])=[CH:4][N:3]=1>CC(C)=O>[Cl:1][C:2]1[N:7]=[C:6]([N:8]([CH:16]([CH3:20])[CH3:17])[C@H:9]([CH2:14][CH3:15])[C:10]([O:12][CH3:13])=[O:11])[C:5]([N+:21]([O-:23])=[O:22])=[CH:4][N:3]=1

Participants

3

Reactant 1

HCID 58405447(R)-Methyl 2-((2-chloro-5-nitropyrimidin-4-yl)(cyclopentyl)amino)butanoate

Product 1

HCID 59815009(R)-methyl 2-((2-chloro-5-nitropyrimidin-4-yl)(isopropyl)amino)butanoate

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Intermediate C-1 was prepared similarly to the synthetic methods used to prepare Intermediate A with the exception that acetone was used instead of cyclopentanone in the reductive amination step.

Workup

  1. customIntermediate C-1 was prepared similarly to the synthetic methods

Sources & evidence

ORD record
ord-70504879d261429a8348f1526e580ab1
Source dataset
uspto-grants-2013_05
Patent number
US08445503B2

Reaction notes

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