反应详情

温度

80 °C

5.0 g (24.6 mmol) 1-(2-amino-4-(trifluoromethyl)phenyl)ethanone was stirred together with 2.6 ml (24.6 mmol) 3-oxo-hexanoic acid ethyl ester and 5.6 g (24.6 mmol) tin(II) chloride dihydrate for 3 h at RT. The mixture was subsequently heated to 80° C. for 16 h. After cooling to RT, the mixture was diluted with EtOH (25 ml), ice was added and the mixture was stirred for 10 min at RT. The solution was subsequently filtered off and washed with EtOAc. The phases were separated and the aqueous phase was extracted with EtOAc. The organic phases were combined, washed with an aq. Na2-EDTA sol., water and brine, dried over MgSO4 and concentrated in a vacuum. After CC (DCM/hexane 2:1) of the residue, 4.3 g (13.7 mmol, 56%) 4-methyl-2-propyl-7-(trifluoromethyl)quinoline-3-carboxylic acid ethyl ester was obtained.

1. temperatureAfter cooling to RT
2. additionwas added
3. filtrationThe solution was subsequently filtered off
4. washwashed with EtOAc
5. customThe phases were separated
6. extractionthe aqueous phase was extracted with EtOAc
7. washwashed with an aq. Na2-EDTA sol., water and brine
8. dry with materialdried over MgSO4
9. concentrationconcentrated in a vacuum