N-bromobutanimide → HCID 66867126, compound

HRID 2093830Notes

Reaction equation

HRID 2093830 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][C:3]=1[O:9][CH2:10][O:11][CH3:12].[Br:13]N1C(=O)CCC1=O>ClCCl>[Br:13][C:6]1[CH:7]=[C:2]([F:1])[C:3]([O:9][CH2:10][O:11][CH3:12])=[CH:4][C:5]=1[OH:8]

Participants

4

Reactant 2

HCID 67184N-bromobutanimideHCID 66868123HCID 66868123, compound

Product 1

HCID 66867126HCID 66867126, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
-15 °C

Procedure

4-Fluoro-3-methoxymethoxy-phenol from example A1 (6.89 g; 40.0 mmol) is dissolved in dry di-chloromethane (160.0 mL). The stirred solution is cooled to −15° C. N-bromosuccinimide (7.12 g; 40.0 mmol) is added in small portions over one hour. After complete addition the reaction mixture is stirred for another 30 min at −15° C.

Workup

  1. additionAfter complete addition the reaction mixture

Sources & evidence

ORD record
ord-6fd666a8587e4e4b9870f15934a74b6f
Source dataset
uspto-grants-2013_05
Patent number
US08445501B2

Reaction notes

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