Bromomethylcyclopropane → 1-Bromo-2-cyclopropylmethoxy-4-fluoro-5-methoxy-benzene

HRID 2093841Notes

Reaction equation

HRID 2093841 reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[C:5]([F:10])=[CH:4][C:3]=1[OH:11].Br[CH2:13][CH:14]1[CH2:16][CH2:15]1>>[Br:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[C:5]([F:10])=[CH:4][C:3]=1[O:11][CH2:13][CH:14]1[CH2:16][CH2:15]1

Participants

3

Reactant 2

HCID 81503BromomethylcyclopropaneHCID 668665692-Bromo-5-fluoro-4-methoxyphenol

Product 1

HCID 668667661-Bromo-2-cyclopropylmethoxy-4-fluoro-5-methoxy-benzene

Procedure

Starting from 2-bromo-5-fluoro-4-methoxy-phenol (example A3) and bromomethyl-cyclopropane the title compound is obtained as colorless solid.

Sources & evidence

ORD record
ord-9052e86fa3fd4834b50f585cfb8c78ff
Source dataset
uspto-grants-2013_05
Patent number
US08445501B2

Reaction notes

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