Chloromethyl Methyl Ether → 4-Bromo-1-fluoro-2-(methoxymethoxy)benzene

HRID 2093847Notes

Reaction equation

HRID 2093847 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:9])=[C:6]([OH:8])[CH:7]=1.Cl[CH2:11][O:12][CH3:13]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:9])=[C:6]([O:8][CH2:11][O:12][CH3:13])[CH:7]=1

Participants

3

Reactant 2

HCID 7864Chloromethyl Methyl EtherHCID 183421Phenol, 5-bromo-2-fluoro-

Product 1

HCID 668660534-Bromo-1-fluoro-2-(methoxymethoxy)benzene

Procedure

Starting from commercially available 5-bromo-2-fluoro-phenol and 1-chloro-1-methoxy-methane prepared according to literature (Stadlwieser, J. Synthesis 1985, 490) the title compound is obtained as colorless oil.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-a91d15b4ff444fa589e43d231aa31ae0
Source dataset
uspto-grants-2013_05
Patent number
US08445501B2

Reaction notes

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