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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2093847Generated: November 1, 2026

Chloromethyl Methyl Ether → 4-Bromo-1-fluoro-2-(methoxymethoxy)benzene

https://huagongshe.com/reaction/2093847

Reaction equation

Participants

RoleNameHCIDCharge
ReactantChloromethyl Methyl EtherHCID 7864—
ReactantPhenol, 5-bromo-2-fluoro-HCID 183421—
Product4-Bromo-1-fluoro-2-(methoxymethoxy)benzeneHCID 66866053—

Reaction Steps

Starting from commercially available 5-bromo-2-fluoro-phenol and 1-chloro-1-methoxy-methane prepared according to literature (Stadlwieser, J. Synthesis 1985, 490) the title compound is obtained as colorless oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08445501B2
Source datasetuspto-grants-2013_05
ORD IDord-a91d15b4ff444fa589e43d231aa31ae0
Source noteuspto-grants-2013_05