Cyclopropanecarbonyl chloride → HCID 66867426, compound

HRID 2094018Notes

Reaction equation

[NH:1]1[CH2:6][CH2:5][CH:4]([NH:7][C:8]([C:10]2[C:14]3[N:15]=[CH:16][N:17]=[C:18]([C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=4[O:25][CH2:26][CH:27]4[CH2:29][CH2:28]4)[C:13]=3[NH:12][CH:11]=2)=[O:9])[CH2:3][CH2:2]1.[CH:30]1([C:33](Cl)=[O:34])[CH2:32][CH2:31]1>>[CH:30]1([C:33]([N:1]2[CH2:2][CH2:3][CH:4]([NH:7][C:8]([C:10]3[C:14]4[N:15]=[CH:16][N:17]=[C:18]([C:19]5[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=5[O:25][CH2:26][CH:27]5[CH2:28][CH2:29]5)[C:13]=4[NH:12][CH:11]=3)=[O:9])[CH2:5][CH2:6]2)=[O:34])[CH2:32][CH2:31]1

Participants

Reactant 2

HCID 77637Cyclopropanecarbonyl chloride

HCID 66866760HCID 66866760, compound

Product 1

HCID 66867426HCID 66867426, compound

Procedure

Starting from 4-(2-cyclopropylmethoxy-phenyl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid piperidin-4-ylamide (example A162) and cyclopropanecarbonyl chloride the title compound is obtained as colorless solid.

Sources & evidence

ORD record: ord-9e08455aab8a47d5885ebb9951ff83ec
Source dataset: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08445501B2

Reaction notes

Loading…