Cyclopropanecarbonyl chloride → HCID 178523795, compound

HRID 2094049Notes

Reaction equation

Cl.[NH2:2][C@H:3]1[CH2:8][CH2:7][C@H:6]([NH:9][C:10]([C:12]2[C:16]3[N:17]=[CH:18][N:19]=[C:20]([C:21]4[C:29]5[O:28][CH2:27][O:26][C:25]=5[CH:24]=[CH:23][C:22]=4[O:30][CH2:31][CH:32]4[CH2:35][CH2:34][CH2:33]4)[C:15]=3[NH:14][CH:13]=2)=[O:11])[CH2:5][CH2:4]1.[CH:36]1([C:39](Cl)=[O:40])[CH2:38][CH2:37]1>>[CH:36]1([C:39]([NH:2][C@H:3]2[CH2:8][CH2:7][C@H:6]([NH:9][C:10]([C:12]3[C:16]4[N:17]=[CH:18][N:19]=[C:20]([C:21]5[C:29]6[O:28][CH2:27][O:26][C:25]=6[CH:24]=[CH:23][C:22]=5[O:30][CH2:31][CH:32]5[CH2:35][CH2:34][CH2:33]5)[C:15]=4[NH:14][CH:13]=3)=[O:11])[CH2:5][CH2:4]2)=[O:40])[CH2:38][CH2:37]1

Participants

Reactant 2

HCID 77637Cyclopropanecarbonyl chloride

HCID 178479271HCID 178479271, compound

Product 1

HCID 178523795HCID 178523795, compound

Procedure

Starting from trans-4-(5-cyclobutylmethoxy-benzo[1,3]dioxol-4-yl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid (4-amino-cyclohexyl)-amide hydrochloride (example A173) and cyclopropanecarbonyl chloride the title compound is obtained as colorless solid.

Sources & evidence

ORD record: ord-a4d6d8dda9a64d22bc200121b4d01da2
Source dataset: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08445501B2

Reaction notes

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