Cyclopropanecarbonyl chloride → HCID 178496162, compound

HRID 2094076Notes

Reaction equation

HRID 2094076 reaction equation
[NH2:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([NH:8][C:9]([C:11]2[C:15]3[N:16]=[CH:17][N:18]=[C:19]([C:20]4[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][C:21]=4[O:28][CH2:29][CH2:30][O:31][CH3:32])[C:14]=3[NH:13][CH:12]=2)=[O:10])[CH2:4][CH2:3]1.[CH:33]1([C:36](Cl)=[O:37])[CH2:35][CH2:34]1>>[CH:33]1([C:36]([NH:1][C@H:2]2[CH2:7][CH2:6][C@H:5]([NH:8][C:9]([C:11]3[C:15]4[N:16]=[CH:17][N:18]=[C:19]([C:20]5[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][C:21]=5[O:28][CH2:29][CH2:30][O:31][CH3:32])[C:14]=4[NH:13][CH:12]=3)=[O:10])[CH2:4][CH2:3]2)=[O:37])[CH2:35][CH2:34]1

Participants

3

Reactant 2

HCID 77637Cyclopropanecarbonyl chlorideHCID 178496158HCID 178496158, compound

Product 1

HCID 178496162HCID 178496162, compound

Procedure

Starting from trans-4-[4-methoxy-2-(2-methoxy-ethoxy)-phenyl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid (4-amino-cyclohexyl)-amide (example A182) and cyclopropanecarbonyl chloride the title compound was obtained as colorless solid.

Sources & evidence

ORD record
ord-0a2ebfcf015749e98c03ffe14aabd58f
Source dataset
uspto-grants-2013_05
Patent number
US08445501B2

Reaction notes

Loading…