Cyclopropanecarbonyl chloride → HCID 66866354, compound

HRID 2094079Notes

Reaction equation

[NH:1]1[CH2:6][CH2:5][CH:4]([NH:7][C:8]([C:10]2[C:14]3[N:15]=[CH:16][N:17]=[C:18]([C:19]4[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][C:20]=4[O:27][CH2:28][CH2:29][O:30][CH3:31])[C:13]=3[NH:12][CH:11]=2)=[O:9])[CH2:3][CH2:2]1.[CH:32]1([C:35](Cl)=[O:36])[CH2:34][CH2:33]1>>[CH:32]1([C:35]([N:1]2[CH2:6][CH2:5][CH:4]([NH:7][C:8]([C:10]3[C:14]4[N:15]=[CH:16][N:17]=[C:18]([C:19]5[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][C:20]=5[O:27][CH2:28][CH2:29][O:30][CH3:31])[C:13]=4[NH:12][CH:11]=3)=[O:9])[CH2:3][CH2:2]2)=[O:36])[CH2:34][CH2:33]1

Participants

Reactant 2

HCID 77637Cyclopropanecarbonyl chloride

HCID 66866058HCID 66866058, compound

Product 1

HCID 66866354HCID 66866354, compound

Procedure

Starting from 4-[4-methoxy-2-(2-methoxy-ethoxy)-phenyl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid piperidin-4-ylamide (example A184) and cyclopropanecarbonyl chloride the title compound was obtained as colorless solid.

Sources & evidence

ORD record: ord-e97b1e6f24a04febb0b89503fd1433bc
Source dataset: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08445501B2

Reaction notes

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