HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 4-Fluoro-3-methylbenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 4-Fluoro-3-methylbenzoyl chloride | HCID 2774589 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-Fluoro-3-methylbenzamide | HCID 2774578 | — |
Reaction Steps
15.70 g (91.0 mmol) 4-fluoro-3-methyl-benzoic acid chloride dissolved in 30 ml THF are added dropwise to 300 ml of conc. ammonia solution and then stirred for 2 hours at ambient temperature. The precipitate formed is filtered off, washed with water and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08445525B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-bc902fe6c67a471f945057930798152e |
| Source note | uspto-grants-2013_05 |