Ammonia → 4-Fluoro-3-methylbenzamide

HRID 2094246Notes

Reaction equation

HRID 2094246 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][C:3]=1[CH3:11].[NH3:12]>C1COCC1>[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:12])=[O:7])=[CH:4][C:3]=1[CH3:11]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 27745894-Fluoro-3-methylbenzoyl chloride

Product 1

HCID 27745784-Fluoro-3-methylbenzamide

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

15.70 g (91.0 mmol) 4-fluoro-3-methyl-benzoic acid chloride dissolved in 30 ml THF are added dropwise to 300 ml of conc. ammonia solution and then stirred for 2 hours at ambient temperature. The precipitate formed is filtered off, washed with water and dried.

Workup

  1. customThe precipitate formed
  2. filtrationis filtered off
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-bc902fe6c67a471f945057930798152e
Source dataset
uspto-grants-2013_05
Patent number
US08445525B2

Reaction notes

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