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HRID2094253

反应详情

EQUATION

反应方程式

HRID 2094253 的结构方程式

REACTANTS

反应物

3
结构：O=C(O)C(F)(F)F
HCID6422

未命名化合物

结构：O=C(O)c1ccc(N2CCCC2=O)cc1
HCID773130

4-(2-Oxo-pyrrolidin-1-yl)-benzoic acid

C11H11NO3

结构：CSCC[C@H](N)c1nc2cc(Cl)ccc2[nH]1
HCID178503691

未命名化合物

PRODUCTS

生成物

1
结构：CSCC[C@H](NC(=O)c1ccc(N2CCCC2=O)cc1)c1nc2cc(Cl)ccc2[nH]1
HCID178503700

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CS(C)=O
溶剂HCID679

Dimethyl sulfoxide

C2H6OS

PROCEDURE

实验过程

Prepared analogously to Example 27 from 4-(pyrrolidin-2-on-1-yl)-benzoic acid, (1S)-1-(5-chloro-1H-benzimidazol-2-yl)-3-methylsulphanyl-propylamine, PfTU and TEA in DMSO at ambient temperature and subsequent Boc cleaving with TFA analogously to Example 1g.