Lithium Hydroxide → HCID 67048642, compound

HRID 2094256Notes

Reaction equation

HRID 2094256 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[N:12]1[CH2:18][CH2:17][CH2:16][CH2:15][O:14][C:13]1=[O:19])[C:5]([O:7]C)=[O:6].[OH-].[Li+]>C(O)C>[CH3:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[N:12]1[CH2:18][CH2:17][CH2:16][CH2:15][O:14][C:13]1=[O:19])[C:5]([OH:7])=[O:6]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 67048344HCID 67048344, compound

Product 1

HCID 67048642HCID 67048642, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

150 mg (0.57 mmol) methyl 3-methyl-4-([1,3]oxazepan-2-on-3-yl)-benzoate are suspended in 1 ml of ethanol and combined with 0.26 ml (0.87 mmol) 8% aqueous lithium hydroxide solution. The mixture is stirred for 3 hours at ambient temperature and then evaporated down i. vac. The aqueous residue is extracted twice with ethyl acetate, then acidified and extracted twice more with ethyl acetate. The combined organic phases are dried over sodium sulphate and evaporated down i. vac.

Workup

  1. customevaporated down i
  2. extractionThe aqueous residue is extracted twice with ethyl acetate
  3. extractionextracted twice more with ethyl acetate
  4. dry with materialThe combined organic phases are dried over sodium sulphate
  5. customevaporated down i

Sources & evidence

ORD record
ord-d4941f54f2ed4294af6fa909cb270515
Source dataset
uspto-grants-2013_05
Patent number
US08445525B2

Reaction notes

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