反应详情

100 mg (0.61 mmol) methyl 4-amino-3-methyl-benzoate dissolved in 3 ml of pyridine are combined with 82 μl (0.67 mmol) 3-chloropropanesulphonic acid chloride and stirred for 16 hours at ambient temperature. The reaction solution is combined with water and ethyl acetate and then the aqueous phase is again extracted with ethyl acetate. The combined organic phases are dried over sodium sulphate and evaporated down i. vac. The residue is further reacted without any more purification.

1. extractionthe aqueous phase is again extracted with ethyl acetate
2. dry with materialThe combined organic phases are dried over sodium sulphate
3. customevaporated down i
4. customThe residue is further reacted without any more purification