Methyl 4-amino-3-methylbenzoate → Methyl 3-methyl-4-[(1-oxo-4-penten-1-yl)amino]benzoate

HRID 2094274Notes

Reaction equation

HRID 2094274 reaction equation
[NH2:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][C:3]=1[CH3:12]>C1COCC1>[CH3:12][C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][C:2]=1[NH:1][C:6](=[O:7])[CH2:5][CH2:4][CH:3]=[CH2:2])[C:6]([O:8][CH3:9])=[O:7]

Participants

3

Reactant 1

HCID 2736799Methyl 4-amino-3-methylbenzoate

Product 1

HCID 67048349Methyl 3-methyl-4-[(1-oxo-4-penten-1-yl)amino]benzoate

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared analogously to Example 46a from methyl 4-amino-3-methyl-benzoate and 4-pentene-1-acid-chloride in THF with TEA.

Sources & evidence

ORD record
ord-9b5d76da7df24555afbd06ed5a9826f2
Source dataset
uspto-grants-2013_05
Patent number
US08445525B2

Reaction notes

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