反应详情

温度

60 °C

2.25 g (7.51 mmol) methyl 4-(5-chloro-pentanoyl-amino)-3-methoxy-benzoate dissolved in 60 ml DMF are combined with 1.26 g (11.2 mmol) potassium-tert.-butoxide and stirred for 2.5 hours at 60° C. Then the mixture is evaporated down i. vac., the residue is combined with water and extracted with ethyl acetate. The combined organic phases are dried over sodium sulphate, evaporated down i. vac. and the residue obtained is purified by chromatography on silica gel (eluting gradient: petroleum ether/ethyl acetate 3:2->0:1).

1. customThen the mixture is evaporated down i
2. extractionextracted with ethyl acetate
3. dry with materialThe combined organic phases are dried over sodium sulphate
4. customevaporated down i
5. customand the residue obtained
6. customis purified by chromatography on silica gel (eluting gradient: petroleum ether/ethyl acetate 3:2->0:1)