Methyl iodide → HCID 69206035, compound

HRID 2094282Notes

Reaction equation

HRID 2094282 reaction equation
[O:1]=[S:2]1(=[O:19])[NH:7][CH2:6][CH2:5][CH2:4][N:3]1[C:8]1[CH:17]=[CH:16][C:11]([C:12]([O:14][CH3:15])=[O:13])=[CH:10][C:9]=1[CH3:18].[K].[CH3:21]C(C)([O-])C.CI>CN(C=O)C>[O:19]=[S:2]1(=[O:1])[N:7]([CH3:21])[CH2:6][CH2:5][CH2:4][N:3]1[C:8]1[CH:17]=[CH:16][C:11]([C:12]([O:14][CH3:15])=[O:13])=[CH:10][C:9]=1[CH3:18]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 50987170Potassium tertbutoxideHCID 67048477HCID 67048477, compound

Product 1

HCID 69206035HCID 69206035, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
40 °C

Procedure

400 mg (1.41 mmol) methyl 4-(1,1-dioxo-[1,2,6]-thiadiazinan-2-yl)-3-methyl-benzoate dissolved in 4 ml DMF at 40° C. are combined with 240 mg (2.14 mmol) potassium-tert.-butoxide and 96 μl (1.54 mmol) methyl iodide and stirred for 5 hours at 40° C. The reaction solution is evaporated down i. vac., combined with water and the aqueous phase is extracted with ethyl acetate. The combined organic phases are dried over sodium sulphate and evaporated down i. vac.

Workup

  1. customThe reaction solution is evaporated down i
  2. extractionthe aqueous phase is extracted with ethyl acetate
  3. dry with materialThe combined organic phases are dried over sodium sulphate
  4. customevaporated down i

Sources & evidence

ORD record
ord-9fc10943dcef4954a3b3a2207613fa1a
Source dataset
uspto-grants-2013_05
Patent number
US08445525B2

Reaction notes

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