Water → 3-Chloro-4-(3,6-dihydro-[1,2]oxazin-2-yl)-benzoic acid

HRID 2094296Notes

Reaction equation

HRID 2094296 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[N:12]1[CH2:17][CH:16]=[CH:15][CH2:14][O:13]1)[C:5]([O:7]C)=[O:6].[OH-].[Na+].O>C(O)C>[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[N:12]1[CH2:17][CH:16]=[CH:15][CH2:14][O:13]1)[C:5]([OH:7])=[O:6]

Participants

5

Reactant 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 67048463Methyl 3-chloro-4-(3,6-dihydro-[1,2]oxazin-2-yl)-benzoate

Product 1

HCID 670485203-Chloro-4-(3,6-dihydro-[1,2]oxazin-2-yl)-benzoic acid

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Prepared analogously to Example 2d from methyl 3-chloro-4-(3,6-dihydro-[1,2]oxazin-2-yl)-benzoate and sodium hydroxide in a solvent mixture of water and ethanol.

Sources & evidence

ORD record
ord-2870d389c2bb4490a51c9d5e63212407
Source dataset
uspto-grants-2013_05
Patent number
US08445525B2

Reaction notes

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