反应详情

1.27 g (4.29 mmol) 2-chloro-N-(4-chlorbutyl-sulphonyl)-4-methyl-aniline are stirred together with 722 mg (6.43 mmol) potassium-tert.-butoxide in 50 ml DMF for 16 hours at 60° C. Then the reaction mixture is poured into water and extracted with ethyl acetate. The combined organic phases are dried over sodium sulphate and evaporated down i. vac. The residue is purified by chromatography on silica gel (eluant: petroleum ether/ethyl acetate=3:2).

1. extractionextracted with ethyl acetate
2. dry with materialThe combined organic phases are dried over sodium sulphate
3. customevaporated down i
4. customThe residue is purified by chromatography on silica gel (eluant: petroleum ether/ethyl acetate=3:2)