反应详情

The compound of step 1 (0.500 g, 1.42 mmol) was dissolved in THF (5 ml) and cooled in an ice bath. Sodium borohydride (0.164 g, 4.25 mmol) was added. Subsequently methanol (2 ml) was added dropwise. After 1 h, the volatiles were evaporated, the residue was partitioned between diethyl ether and a saturated sodium hydrogencarbonate solution, and the aqueous phase extracted with diethyl ether. The combined organic phases were dried over sodium sulfate and evaporated to dryness.

1. temperaturecooled in an ice bath
2. customthe volatiles were evaporated
3. customthe residue was partitioned between diethyl ether
4. extractiona saturated sodium hydrogencarbonate solution, and the aqueous phase extracted with diethyl ether
5. dry with materialThe combined organic phases were dried over sodium sulfate
6. customevaporated to dryness