Hydrazine → HCID 178509224, compound

HRID 2094772Notes

Reaction equation

HRID 2094772 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:9]#[N:10])[C:5](Cl)=[N:6][CH:7]=1.[NH2:11][NH2:12]>CCO>[Br:1][C:2]1[CH:3]=[C:4]2[C:9]([NH2:10])=[N:12][NH:11][C:5]2=[N:6][CH:7]=1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 219482695-Bromo-2-chloronicotinonitrile

Product 1

HCID 178509224HCID 178509224, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Compound 3 (307 mg, 1.4 mmol) was dissolved in EtOH (10 mL) in a microwave tube, to which 5 equivalent of NH2NH2 was added, and the reaction mixture was put on Microwave irradiation for 10 min at 170° C. Evaporated the solvent to obtain the title compound 4 in quantitative yield.

Workup

  1. additionwas added
  2. customthe reaction mixture was put on Microwave irradiation for 10 min at 170° C
  3. customEvaporated the solvent

Sources & evidence

ORD record
ord-713c2ba8a5034976aa98cf4d83b5ae02
Source dataset
uspto-grants-2013_05
Patent number
US08445681B2

Reaction notes

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