Water → HCID 45095769, compound

HRID 2094798Notes

Reaction equation

HRID 2094798 reaction equation
BrBr.[K+].[Br-:4].[CH2:5]([C:7]1[CH:8]=[CH:9][C:10]([CH:13]=[CH2:14])=[N:11][CH:12]=1)[CH3:6].[OH2:15]>>[Br:4][CH2:14][CH:13]([C:10]1[CH:9]=[CH:8][C:7]([CH2:5][CH3:6])=[CH:12][N:11]=1)[OH:15]

Participants

5

Reactant 4

HCID 962WaterHCID 24408BromineHCID 222462Pyridine, 5-ethyl-2-vinyl-HCID 253877Potassium Bromide

Product 1

HCID 45095769HCID 45095769, compoundYield 86%

Conditions

Temperature
62.5 °C

Procedure

5.5 g (0.0344 mol) liq. Bromine was added to a solution of 7.83 g (0.0658 mol) KBr dissolved in 100 mL water. Reaction mixture was heated to 60-65° C. and 5 g (0.0376 mmol) of 5-ethyl-2-vinyl-pyridine was added into it in 10 min. Reaction mixture was stirred for 30 min and quenched with excess of water. Product was extracted with dichloromethane, which was separated, dried, concentrated and purified to get 7.43 g (86%) of the titled product.

Workup

  1. customReaction mixture
  2. customReaction mixture
  3. customquenched with excess of water
  4. extractionProduct was extracted with dichloromethane, which
  5. customwas separated
  6. customdried
  7. concentrationconcentrated
  8. custompurified

Sources & evidence

ORD record
ord-742c3c15f8b44b1aa4b4c0a07ef76b92
Source dataset
uspto-grants-2013_05
Patent number
US08445685B2

Reaction notes

Loading…