HCID 49830481, compound → HCID 68515201, compound

HRID 2094826Notes

Reaction equation

HRID 2094826 reaction equation
[NH2:1][CH2:2][CH:3]([NH:10][C:11](=[O:24])[C:12]1[CH:17]=[CH:16][C:15]([C:18]2[CH:23]=[CH:22][N:21]=[CH:20][CH:19]=2)=[CH:14][CH:13]=1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>CCCCCC.CCO.CO>[NH2:1][CH2:2][C@H:3]([NH:10][C:11](=[O:24])[C:12]1[CH:17]=[CH:16][C:15]([C:18]2[CH:19]=[CH:20][N:21]=[CH:22][CH:23]=2)=[CH:14][CH:13]=1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

3

Reactant 1

HCID 49830481HCID 49830481, compound

Product 1

HCID 68515201HCID 68515201, compound

Reagents, catalysts & solvents 1

HCID 18509146HCID 18509146, compoundSolvent

Procedure

The title compounds were prepared by subjecting the compound of Example 4 to a column chromatography with a chiral stationary phase (Prep HPLC; column: Whelk O 2.5 cm ID×25 cm; mobile phase: hexane/EtOH/MeOH/DEA=50/25/25/0.1; flow rate: 40 ml/min; detector: UV 270 nm; column temp: RT; sample preparation: 10 mg/ml; load: 10 ml (100 mg))

Sources & evidence

ORD record
ord-3a362975e38f4a9b9f71c57d58588407
Source dataset
uspto-grants-2013_05
Patent number
US08445686B2

Reaction notes

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