Pyrimidin-5-ylmethanamine → HCID 178518107, compound

HRID 2094840Notes

Reaction equation

HRID 2094840 reaction equation
[F:1][C:2]([F:33])([F:32])[C:3]1[CH:27]=[C:26]([C:28]([F:31])([F:30])[F:29])[CH:25]=[CH:24][C:4]=1[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11]([CH:15]=[C:16]3[S:20][C:19](SC)=[N:18][C:17]3=[O:23])=[CH:12][CH:13]=2)[CH:8]=[N:7]1.[N:34]1[CH:39]=[C:38]([CH2:40][NH2:41])[CH:37]=[N:36][CH:35]=1>>[F:1][C:2]([F:32])([F:33])[C:3]1[CH:27]=[C:26]([C:28]([F:29])([F:30])[F:31])[CH:25]=[CH:24][C:4]=1[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11]([CH:15]=[C:16]3[S:20][C:19]([NH:41][CH2:40][C:38]4[CH:39]=[N:34][CH:35]=[N:36][CH:37]=4)=[N:18][C:17]3=[O:23])=[CH:12][CH:13]=2)[CH:8]=[N:7]1

Participants

3

Reactant 2

HCID 18953632Pyrimidin-5-ylmethanamineHCID 866545435-[1-(2,4-bis-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]2-methylsulfanyl-thiazol-4-one

Product 1

HCID 178518107HCID 178518107, compound

Procedure

5-[1-(2,4-Bis-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-[(pyrimidin-5-ylmethyl)-amino]-thiazol-4-one was prepared from 5-[1-(2,4-Bis-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-methylsulfanyl-thiazol-4-one and C-pyrimidin-5-yl-methylamine following General Procedure B.

Sources & evidence

ORD record
ord-22ef90134462433bb7114cabcecef9cf
Source dataset
uspto-grants-2013_05
Patent number
US08445690B2

Reaction notes

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