Pyrimidin-5-ylmethanamine → HCID 178518108, compound

HRID 2094844Notes

Reaction equation

HRID 2094844 reaction equation
[Cl:1][C:2]1[CH:26]=[CH:25][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([CH:16]=[C:17]4[S:21][CH:20](SC)[NH:19][C:18]4=[O:24])=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:27]([F:30])([F:29])[F:28])[CH:3]=1.[N:31]1[CH:36]=[C:35]([CH2:37][NH2:38])[CH:34]=[N:33][CH:32]=1>>[Cl:1][C:2]1[CH:26]=[CH:25][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([CH:16]=[C:17]4[S:21][C:20]([NH:38][CH2:37][C:35]5[CH:36]=[N:31][CH:32]=[N:33][CH:34]=5)=[N:19][C:18]4=[O:24])=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:27]([F:28])([F:30])[F:29])[CH:3]=1

Participants

3

Reactant 2

HCID 18953632Pyrimidin-5-ylmethanamineHCID 866565225-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-methylsulfanyl-thiazolidin-4-one

Product 1

HCID 178518108HCID 178518108, compound

Procedure

5-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-[(pyrimidin-5-ylmethyl)-amino]-thiazol-4-one was prepared from 5-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-methylsulfanyl-thiazolidin-4-one and C-Pyrimidin-5-yl-methylamine following General Procedure B.

Sources & evidence

ORD record
ord-b81bed74c0b84f72833f8d1d413f850b
Source dataset
uspto-grants-2013_05
Patent number
US08445690B2

Reaction notes

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