Triethylamine → 3-chloro-N-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-4-(methylsulfonyl)thiophene-2-carboxamide

HRID 2094854Notes

Reaction equation

HRID 2094854 reaction equation
Cl.[CH3:2][C:3]1[C:7]([CH2:8][N:9]2[CH:13]=[C:12]([NH2:14])[CH:11]=[N:10]2)=[C:6]([CH3:15])[O:5][N:4]=1.C(N(CC)CC)C.[Cl:23][C:24]1[C:28]([S:29]([CH3:32])(=[O:31])=[O:30])=[CH:27][S:26][C:25]=1[C:33](Cl)=[O:34]>C(Cl)Cl.CC#N>[Cl:23][C:24]1[C:28]([S:29]([CH3:32])(=[O:30])=[O:31])=[CH:27][S:26][C:25]=1[C:33]([NH:14][C:12]1[CH:11]=[N:10][N:9]([CH2:8][C:7]2[C:3]([CH3:2])=[N:4][O:5][C:6]=2[CH3:15])[CH:13]=1)=[O:34]

Participants

6

Reactant 3

HCID 8471TriethylamineHCID 27357753-Chloro-4-(Methylsulfonyl)Thiophene-2-Carbonyl ChlorideHCID 574222641-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-amine hydrochloride

Product 1

HCID 43413323-chloro-N-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-4-(methylsulfonyl)thiophene-2-carboxamideYield 45.2%

Reagents, catalysts & solvents 2

HCID 6342AcetonitrileSolventHCID 6344DichloromethaneSolvent

Conditions

Temperature
0 °C

Procedure

To a stirring mixture of ((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-amine hydrochloride (Example 4-1a) (500 mg, 2 mmol) in DCM (20 mL), cooled to 0° C. via an ice water bath, was added triethylamine (600 mg, 6 mmol). The mixture was stirred until all solids were in solution (˜10 minutes). 3-Chloro-4-(methylsulfonyl)thiophene-2-carbonyl chloride (543 mg, 2.1 mmol), in 2 mL CH3CN, was added via syringe to the free amine at 0° C. The ice bath was removed and the mixture was stirred for 2 hours. The reaction was diluted with dichloromethane (100 mL) and the organic phase was washed with H2O (200 mL). The organic layer was dried over sodium sulfate, filtered and concentrated under reduced pressure. The solid was triturated with ethyl acetate/hexanes (1/5) to afford 3-chloro-N-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-4 (methylsulfonyl)thiophene-2-carboxamide (375 mg, 45%) as a white solid. 1H NMR (CDCl3, 400 MHz): 2.20 (s, 3H), 2.43 (s, 4H), 3.22 (s, 3H), 5.05 (s, 2H), 7.57 (s, 1H), 7.94 (s, 1H), 8.41 (s, 1H), 8.59 (bs, 1H). LC/MS; [M+H] 415.5. Melting point: 202-204° C.

Workup

  1. customwere in solution (˜10 minutes)
  2. customThe ice bath was removed
  3. stirringthe mixture was stirred for 2 hours
  4. additionThe reaction was diluted with dichloromethane (100 mL)
  5. washthe organic phase was washed with H2O (200 mL)
  6. dry with materialThe organic layer was dried over sodium sulfate
  7. filtrationfiltered
  8. concentrationconcentrated under reduced pressure
  9. customThe solid was triturated with ethyl acetate/hexanes (1/5)

Sources & evidence

ORD record
ord-5ede9cbcf8b1430c869d22af642eabbc
Source dataset
uspto-grants-2013_05
Patent number
US08445692B2

Reaction notes

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