3-Methoxybenzyl bromide → HCID 25207618, compound

HRID 2094913Notes

Reaction equation

HRID 2094913 reaction equation
[CH3:1][O:2][C:3]1[CH:23]=[CH:22][C:6]([CH2:7][NH:8][S:9]([C:12]2[CH:21]=[CH:20][C:15]([C:16]([O:18]C)=[O:17])=[CH:14][CH:13]=2)(=[O:11])=[O:10])=[CH:5][CH:4]=1.[CH3:24][O:25][C:26]1[CH:27]=[C:28]([CH:31]=[CH:32][CH:33]=1)[CH2:29]Br>>[CH3:24][O:25][C:26]1[CH:27]=[C:28]([CH:31]=[CH:32][CH:33]=1)[CH2:29][N:8]([CH2:7][C:6]1[CH:22]=[CH:23][C:3]([O:2][CH3:1])=[CH:4][CH:5]=1)[S:9]([C:12]1[CH:21]=[CH:20][C:15]([C:16]([OH:18])=[O:17])=[CH:14][CH:13]=1)(=[O:11])=[O:10]

Participants

3

Reactant 2

HCID 40672073-Methoxybenzyl bromideHCID 26527056Methyl 4-(N-(4-methoxybenzyl)sulfamoyl)benzoate

Product 1

HCID 25207618HCID 25207618, compound

Procedure

Prepared as in example 5-10 from Methyl 4-(N-(4-methoxybenzyl)sulfamoyl)benzoate (Example 5-10b) and 3-methoxybenzyl bromide. MS (M−H, 440.50); 1H NMR (400 MHz, DMSO-d6): δ, ppm: 3.58(s, 3H), 3.68(s, 3H), 4.24(s, 2H), 4.25(s, 2H), 6.50(s, 1H), 6.64(d, J=4 Hz, 1H), 6.73(m, 1H), 6.77(d, J=8 Hz, 2H), 7.00(d, J=8 Hz, 2H), 7.12(t, J=8 Hz, 1H), 7.94(d, J=8 Hz, 2H), 8.09(d, J=8 Hz, 2H), 13.49(s, 1H).

Sources & evidence

ORD record
ord-565e7a77e7994d8f818c2efe4c5ad7db
Source dataset
uspto-grants-2013_05
Patent number
US08445692B2

Reaction notes

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