Hydrochloric Acid → HCID 19689357, compound

HRID 2095Notes

Reaction equation

HRID 2095 reaction equation
[Cl:1][C:2]1[CH:28]=[CH:27][C:5]([CH:6]([NH:21][NH:22][C:23]([O:25][CH3:26])=[O:24])[C:7]2[CH:12]=[CH:11][C:10]([CH2:13][S:14]([C:17]([F:20])([F:19])[F:18])(=[O:16])=[O:15])=[CH:9][CH:8]=2)=[CH:4][CH:3]=1.Cl>CO>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:6]([NH:21][NH:22][C:23]([O:25][CH3:26])=[O:24])[C:7]2[CH:12]=[CH:11][C:10]([CH2:13][S:14]([C:17]([F:20])([F:19])[F:18])(=[O:15])=[O:16])=[CH:9][CH:8]=2)=[CH:27][CH:28]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 19689358HCID 19689358, compound

Product 1

HCID 19689357HCID 19689357, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

N-(4-chloro-4'-trifluoromethylsulfonylmethylbenzhydryl) -N'-methoxycarbonylhydrazine (1.6 g) was added to methanol (80 ml), and hydrochloric acid (3 ml) was added thereto with stirring at room temperature. The mixture was gradually heated to the reflux temperature and stirred for 2 hours under reflux, and then it was left to cool. The solvent was distilled off under reduced pressure to obtain the desired product as a slightly yellow powder (1.6 g, melting point: 52° to 54° C., yield: 91.5%).

Workup

  1. additionwas added
  2. temperatureThe mixture was gradually heated to the reflux temperature
  3. stirringstirred for 2 hours
  4. temperatureunder reflux
  5. waitit was left
  6. temperatureto cool
  7. distillationThe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-3e56139cc6e34a43b00746088801690f
Source dataset
uspto-grants-1998_03
Patent number
US05728699

Reaction notes

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