反应详情

N-(4-chloro-4'-trifluoromethylsulfonylmethylbenzhydryl) -N'-methoxycarbonylhydrazine (1.6 g) was added to methanol (80 ml), and hydrochloric acid (3 ml) was added thereto with stirring at room temperature. The mixture was gradually heated to the reflux temperature and stirred for 2 hours under reflux, and then it was left to cool. The solvent was distilled off under reduced pressure to obtain the desired product as a slightly yellow powder (1.6 g, melting point: 52° to 54° C., yield: 91.5%).

1. additionwas added
2. temperatureThe mixture was gradually heated to the reflux temperature
3. stirringstirred for 2 hours
4. temperatureunder reflux
5. waitit was left
6. temperatureto cool
7. distillationThe solvent was distilled off under reduced pressure