Methanesulfonyl chloride → HCID 178505090, compound

HRID 2095172Notes

Reaction equation

HRID 2095172 reaction equation
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[NH2:6][CH2:7][C:8]1[C:9](=[N:14][NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([F:22])[CH:17]=2)[C:10]([NH2:13])=[N:11][N:12]=1>CN(C=O)C>[NH2:13][C:10]1[C:9](=[N:14][NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([F:22])[CH:17]=2)[C:8]([CH2:7][NH:6][S:2]([CH3:1])(=[O:4])=[O:3])=[N:12][N:11]=1

Participants

4

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 178510679HCID 178510679, compound

Product 1

HCID 178505090HCID 178505090, compoundYield 52%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Methanesulfonyl chloride was reacted with 5-(aminomethyl)-4-(3-fluorophenylhydrazono)-3-amino-4H-pyrazole (60 mg, 0.25 mmole) in DMF at ambient temperature to yield 43 mg (52%) of the title compound. 1H NMR (ppm, 300 MHz, DMSO-d6) δ 11.49 (br s, 1H), 7.20-7.50 (m, 3H), 6.70-7.10 (m, 2H), 6.45 (br s, NH2), 4.40 (d, 2H), 2.79 (s, 3H, CH3).

Sources & evidence

ORD record
ord-0a30995aba1d48b796bd8e650b75e0d1
Source dataset
uspto-grants-2013_05
Patent number
US08445694B2

Reaction notes

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