Hydrogen Bromide → (4-Bromo-3-trifluoromethyl-phenyl)-morpholin-4-yl-methanone

HRID 2095260Notes

Reaction equation

HRID 2095260 reaction equation
N[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)=[O:9])=[CH:4][C:3]=1[C:16]([F:19])([F:18])[F:17].OS(O)(=O)=O.N([O-])=O.[Na+].[BrH:29]>O>[Br:29][C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)=[O:9])=[CH:4][C:3]=1[C:16]([F:19])([F:18])[F:17]

Participants

6

Reactant 4

HCID 260Hydrogen BromideHCID 1118Sulfuric AcidHCID 23668193Sodium NitriteHCID 62155530(4-Amino-3-(trifluoromethyl)phenyl)(morpholino)methanone

Product 1

HCID 68941524(4-Bromo-3-trifluoromethyl-phenyl)-morpholin-4-yl-methanone

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

To a mixture of EXAMPLE 144B (8.3 g) was added water (75 mL) and H2SO4 (25 mL). The mixture was stirred at 0° C. while NaNO2 (3.13 g) in water (30 mL) was added. After stirring for 1 hour, the mixture was added to CuBr (5.45 g) in 48% HBr (200 mL). This mixture was stirred at 60° C. for 3 hours, cooled to room temperature, and partitioned between water and ethyl acetate. The organic layer was washed with aqueous Na2CO3 and dried (Na2SO4), filtered and concentrated.

Workup

  1. additionwas added
  2. stirringThis mixture was stirred at 60° C. for 3 hours
  3. custompartitioned between water and ethyl acetate
  4. washThe organic layer was washed with aqueous Na2CO3
  5. dry with materialdried (Na2SO4)
  6. filtrationfiltered
  7. concentrationconcentrated

Sources & evidence

ORD record
ord-1af3aef3c3c14f6f993c2420fdbda9e7
Source dataset
uspto-grants-2013_05
Patent number
US08445679B2

Reaction notes

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