Hydrochloric Acid → HCID 68612180, compound

HRID 2095307Notes

Reaction equation

HRID 2095307 reaction equation
[ClH:1].C(OC([N:9]1[CH2:12][CH2:11][C@H:10]1[CH2:13][O:14][C:15]1[CH:16]=[C:17]([CH2:21][C@@H:22]2[CH2:24][C@H:23]2[CH2:25][OH:26])[CH:18]=[N:19][CH:20]=1)=O)(C)(C)C>CCOCC.CO>[ClH:1].[NH:9]1[CH2:12][CH2:11][C@H:10]1[CH2:13][O:14][C:15]1[CH:16]=[C:17]([CH2:21][C@@H:22]2[CH2:24][C@H:23]2[CH2:25][OH:26])[CH:18]=[N:19][CH:20]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 68611342HCID 68611342, compound

Product 1

HCID 68612180HCID 68612180, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 3283Diethyl EtherSolvent

Procedure

2M anhydrous HCl in ether is added to a stirred solution of (1R,2S)-2-[[5-[[1-(tert-butoxycarbonyl)-2(S)-azetidinyl]methoxy]-3-pyridyl]methyl]cyclopropylmethanol in dry MeOH at 0° C. The mixture is stirred at room temperature overnight and the conversion of starting material confirmed by TLC. The above solution is concentrated and purified by HPLC to obtain the title compound.

Workup

  1. concentrationThe above solution is concentrated
  2. custompurified by HPLC

Sources & evidence

ORD record
ord-af6f5f5f88dc4c7683c2c7739c654ced
Source dataset
uspto-grants-2013_05
Patent number
US08445684B2

Reaction notes

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