Hydrochloric Acid → HCID 67074220, compound

HRID 2095490Notes

Reaction equation

HRID 2095490 reaction equation
C([O:5][C:6](=[O:28])[CH2:7][CH2:8][N:9]1[CH2:14][CH2:13][N:12]([C:15](=[O:25])[NH:16][C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[C:19]([Cl:24])[CH:18]=2)[C@@H:11]([CH3:26])[C:10]1=[O:27])(C)(C)C.Cl>ClCCl>[Cl:24][C:19]1[CH:18]=[C:17]([NH:16][C:15]([N:12]2[CH2:13][CH2:14][N:9]([CH2:8][CH2:7][C:6]([OH:28])=[O:5])[C:10](=[O:27])[C@@H:11]2[CH3:26])=[O:25])[CH:22]=[CH:21][C:20]=1[Cl:23]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67074021HCID 67074021, compound

Product 1

HCID 67074220HCID 67074220, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 0.45 g (1.10 mmol) of 3-[(S)-4-(3,4-dichloro-phenylcarbamoyl)-3-methyl-2-oxo-piperazin-1-yl]-propionic acid tert-butyl ester in 3.0 ml of dichloromethane was treated at 0° C. with 5.40 ml (21.60 mmol, 4 M in dioxane) of HCl and stirred and warmed up to RT over night. The reaction was evaporated, dissolved in toluene and evaporated (3×) to give 0.52 g (quant.) of the titled compound as light yellow foam. MS: 372.1 (M−H−, 2Cl).

Workup

  1. customThe reaction was evaporated
  2. dissolutiondissolved in toluene
  3. customevaporated (3×)

Sources & evidence

ORD record
ord-2698063acd0741e59701ad43a9e272b8
Source dataset
uspto-grants-2013_05
Patent number
US08445674B2

Reaction notes

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