HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane methanol → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane methanol | HCID 21226129 | — |
| Reactant | (4S)-6-Azaspiro[2.5]octan-4-ol | HCID 44541813 | — |
| Reactant | (S)-4-(4-carboxy-butyl)-2-methyl-3-oxo-piperazine-1-carboxylic acid benzyl ester | HCID 67074539 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | (S)-4-[5-((S)-4-Hydroxy-6-aza-spiro[2.5]oct-6-yl)-5-oxo-pentyl]-2-methyl-3-oxo-piperazine-1-carboxylic acid benzyl ester | HCID 67074445 | — |
Reaction Steps
In analogy to the procedure described in Example 15, (S)-4-(4-carboxy-butyl)-2-methyl-3-oxo-piperazine-1-carboxylic acid benzyl ester and 1.1 eq. of (S)-6-aza-spiro[2.5]octan-4-ol; hydrochloride (intermediate 2) gave after flash chromatography (SiO2, dichloromethane/MeOH 100% dichloromethane to 85/15) the titled compound in 61% yield as light yellow amorphous solid. MS: 458.26 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08445674B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-cb454445c40c494883b83ffd40e66edc |
| Source note | uspto-grants-2013_05 |