huagongshe.com
HRID2095494

反应详情

EQUATION

反应方程式

HRID 2095494 的结构方程式

REACTANTS

反应物

3
结构：CO.ClCCl
HCID21226129

未命名化合物

结构：O[C@@H]1CNCCC12CC2
HCID44541813

未命名化合物

结构：C[C@H]1C(=O)N(CCCCC(=O)O)CCN1C(=O)OCc1ccccc1
HCID67074539

未命名化合物

PRODUCTS

生成物

2
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：C[C@H]1C(=O)N(CCCCC(=O)N2CCC3(CC3)[C@H](O)C2)CCN1C(=O)OCc1ccccc1
HCID67074445

未命名化合物

PROCEDURE

实验过程

In analogy to the procedure described in Example 15, (S)-4-(4-carboxy-butyl)-2-methyl-3-oxo-piperazine-1-carboxylic acid benzyl ester and 1.1 eq. of (S)-6-aza-spiro[2.5]octan-4-ol; hydrochloride (intermediate 2) gave after flash chromatography (SiO2, dichloromethane/MeOH 100% dichloromethane to 85/15) the titled compound in 61% yield as light yellow amorphous solid. MS: 458.26 (MH+).