Lithium Hydroxide → HCID 67074652, compound

HRID 2095500Notes

Reaction equation

[CH2:1]([O:8][C:9]([N:11]1[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][C:19]([C:22]([O:24]C)=[O:23])([CH3:21])[CH3:20])[C:13](=[O:26])[C@@H:12]1[CH3:27])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Li+]>>[CH2:1]([O:8][C:9]([N:11]1[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][C:19]([C:22]([OH:24])=[O:23])([CH3:20])[CH3:21])[C:13](=[O:26])[C@@H:12]1[CH3:27])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 67074248HCID 67074248, compound

Product 1

HCID 67074652HCID 67074652, compoundYield 70%

Procedure

In analogy to the procedure described in Example 23B, (S)-4-(3-methoxycarbonyl-3-methyl-butyl)-2-methyl-3-oxo-piperazine-1-carboxylic acid benzyl ester and 1 M aq. lithium hydroxide solution gave the titled compound in 70% yield as light yellow oil. MS: 363.19 (MH+).

Sources & evidence

ORD record: ord-ffec92b7dbfd4ae1b95a2d6adfc3a656
Source dataset: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08445674B2

Reaction notes

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