HRID2095527

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID3939

Lithium hydroxide anhydrous

HLiO

结构：COC(=O)C[C@H](O)CN1CCN(c2ccc(C(F)(F)F)c(Cl)c2)[C@@H](C)C1=O

HCID67074330

未命名化合物

PRODUCTS

生成物

结构：C[C@H]1C(=O)N(C[C@@H](O)CC(=O)O)CCN1c1ccc(C(F)(F)F)c(Cl)c1

HCID67074550

未命名化合物

收率 82%

PROCEDURE

实验过程

In analogy to intermediate 3B, (S)-4-[(S)-4-(3-chloro-4-trifluoromethyl-phenyl)-3-methyl-2-oxo-piperazin-1-yl]-3-hydroxy-butyric acid methyl ester was hydrolyzed with 1 M aqueous lithium hydroxide (1 h) to give after extraction (EtOAc) and precipitation (dichloromethane/n-pentane) the titled compound in 82% yield as light yellow foam. MS: 393.08 (MH+)

WORKUP

后处理

customto give
extractionafter extraction (EtOAc) and precipitation (dichloromethane/n-pentane) the titled compound in 82% yield as light yellow foam