4-Methylpiperidin-4-ol → HCID 58232093, compound

HRID 2095551Notes

Reaction equation

HRID 2095551 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]([N:12]2[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][C:20](O)=[O:21])[C:14](=[O:23])[C@@H:13]2[CH3:24])=[O:11])[CH:5]=[CH:6][C:7]=1[Cl:8].[CH3:25][C:26]1([OH:32])[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1>>[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]([N:12]2[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][C:20]([N:29]3[CH2:30][CH2:31][C:26]([OH:32])([CH3:25])[CH2:27][CH2:28]3)=[O:21])[C:14](=[O:23])[C@@H:13]2[CH3:24])=[O:11])[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

3

Reactant 2

HCID 156491744-Methylpiperidin-4-olHCID 67074220HCID 67074220, compound2×

Product 1

HCID 58232093HCID 58232093, compoundYield 51%

Procedure

In analogy to the procedure described in Example 15, 3-[(S)-4-(3,4-dichloro-phenylcarbamoyl)-3-methyl-2-oxo-piperazin-1-yl]-propionic acid (intermediate 12) and 4-methyl-piperidin-4-ol gave the titled compound in 51% yield as off-white solid. MS: 471.2 (MH+, 2Cl).

Sources & evidence

ORD record
ord-ccd61bd143674574951a34eaf701d898
Source dataset
uspto-grants-2013_05
Patent number
US08445674B2

Reaction notes

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