HRID2095555

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID16218160

4-(Trifluoromethyl)piperidine--hydrogen chloride (1/1)

C6H11ClF3N

反应SMILES：C[C@H]1C(=O)N(CCC(=O)O)CCN1C(=O)Nc1ccc(Cl)c(Cl)c1

HCID67074220

未命名化合物

2 次

PRODUCTS

产物

反应SMILES：C[C@H]1C(=O)N(CCC(=O)N2CCC(C(F)(F)F)CC2)CCN1C(=O)Nc1ccc(Cl)c(Cl)c1

HCID67074663

未命名化合物

收率 31%

PROCEDURE

实验过程

In analogy to the procedure described in Example 15, 3-[(S)-4-(3,4-dichloro-phenylcarbamoyl)-3-methyl-2-oxo-piperazin-1-yl]-propionic acid (intermediate 12) and 4-trifluoromethyl-piperidine hydrochloride gave the titled compound in 31% yield as white foam. MS: 509.13 (MH+, 2Cl).