HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Trifluoromethyl)phenyl isocyanate → (S)-4-[4-((S)-4-Hydroxy-6-aza-spiro[2.5]oct-6-yl)-4-oxo-butyl]-2-methyl-3-oxo-piperazine-1-carboxylic acid (4-trifluoromethyl-phenyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Trifluoromethyl)phenyl isocyanate | HCID 73768 | — |
| Reactant | HCID 67074162 | HCID 67074162 | — |
| Product | (S)-4-[4-((S)-4-Hydroxy-6-aza-spiro[2.5]oct-6-yl)-4-oxo-butyl]-2-methyl-3-oxo-piperazine-1-carboxylic acid (4-trifluoromethyl-phenyl)-amide | HCID 52913245 | 32% |
Reaction Steps
In analogy to the procedure described in Example 25, (S)-1-[4-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-4-oxo-butyl]-3-methyl-piperazin-2-one (intermediate 13) and 4-(trifluoromethyl)phenyl isocyanate gave the titled compound in 32% yield as white foam. MS: 497.2 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08445674B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-c62d428fbf3b4eecbf996b60ef766973 |
| Source note | uspto-grants-2013_05 |