3-(TrifluoroMethoxy)phenyl isocyanate → HCID 67086994, compound

HRID 2095562Notes

Reaction equation

HRID 2095562 reaction equation
[OH:1][C@@H:2]1[CH2:9][N:8]([C:10](=[O:22])[CH2:11][CH2:12][CH2:13][N:14]2[CH2:19][CH2:18][NH:17][C@@H:16]([CH3:20])[C:15]2=[O:21])[CH2:7][CH2:6][C:3]21[CH2:5][CH2:4]2.[N:23]([C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([O:32][C:33]([F:36])([F:35])[F:34])[CH:27]=1)=[C:24]=[O:25]>>[F:34][C:33]([F:35])([F:36])[O:32][C:28]1[CH:27]=[C:26]([NH:23][C:24]([N:17]2[CH2:18][CH2:19][N:14]([CH2:13][CH2:12][CH2:11][C:10]([N:8]3[CH2:7][CH2:6][C:3]4([CH2:5][CH2:4]4)[C@H:2]([OH:1])[CH2:9]3)=[O:22])[C:15](=[O:21])[C@@H:16]2[CH3:20])=[O:25])[CH:31]=[CH:30][CH:29]=1

Participants

3

Reactant 2

HCID 200675553-(TrifluoroMethoxy)phenyl isocyanate2×HCID 67074162HCID 67074162, compound2×

Product 1

HCID 67086994HCID 67086994, compoundYield 70%

Procedure

In analogy to the procedure described in Example 30, (S)-1-[4-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-4-oxo-butyl]-3-methyl-piperazin-2-one (intermediate 13) and 1-isocyanato-3-trifluoromethoxy-benzene (intermediate 15) gave the titled compound in 70% yield as white amorphous solid. MS: 513.23 (MH+).

Sources & evidence

ORD record
ord-873a3be339044784a12e23f0903e10f1
Source dataset
uspto-grants-2013_05
Patent number
US08445674B2

Reaction notes

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