HCID 67074162, compound → HCID 67086935, compound

HRID 2095566Notes

Reaction equation

HRID 2095566 reaction equation
[OH:1][C@@H:2]1[CH2:9][N:8]([C:10](=[O:22])[CH2:11][CH2:12][CH2:13][N:14]2[CH2:19][CH2:18][NH:17][C@@H:16]([CH3:20])[C:15]2=[O:21])[CH2:7][CH2:6][C:3]21[CH2:5][CH2:4]2.[Cl:23][C:24]1[CH:29]=[CH:28][C:27]([N:30]=[C:31]=[O:32])=[CH:26][C:25]=1[O:33][C:34]([F:37])([F:36])[F:35]>>[Cl:23][C:24]1[CH:29]=[CH:28][C:27]([NH:30][C:31]([N:17]2[CH2:18][CH2:19][N:14]([CH2:13][CH2:12][CH2:11][C:10]([N:8]3[CH2:7][CH2:6][C:3]4([CH2:5][CH2:4]4)[C@H:2]([OH:1])[CH2:9]3)=[O:22])[C:15](=[O:21])[C@@H:16]2[CH3:20])=[O:32])=[CH:26][C:25]=1[O:33][C:34]([F:35])([F:37])[F:36]

Participants

3

Reactant 2

HCID 67074162HCID 67074162, compound2×HCID 86652696HCID 86652696, compound2×

Product 1

HCID 67086935HCID 67086935, compoundYield 67%

Procedure

In analogy to the procedure described in Example 30, (S)-1-[4-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-4-oxo-butyl]-3-methyl-piperazin-2-one (intermediate 13) and 1-chloro-4-isocyanato-2-trifluoromethoxy-benzene (intermediate 18) gave the titled compound in 67% yield as light brown foam. MS: 547.19 (MH+, 1Cl).

Sources & evidence

ORD record
ord-9bed9e4cf6cf4656baea414878212528
Source dataset
uspto-grants-2013_05
Patent number
US08445674B2

Reaction notes

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