HRID2095572

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7972

4-Methylmorpholine

C5H11NO

HCID15765405

未命名化合物

2 次

结构：COC(=O)[C@H](CCC(=O)N1CCC2(CC2)[C@H](O)C1)N1CCN[C@@H](C)C1=O

HCID67074057

未命名化合物

2 次

PRODUCTS

生成物

结构：COC(=O)[C@H](CCC(=O)N1CCC2(CC2)[C@H](O)C1)N1CCN(C(=O)Nc2ccc(OC(F)(F)F)c(Cl)c2)[C@@H](C)C1=O

HCID58232194

未命名化合物

收率 67%

PROCEDURE

实验过程

In analogy to the procedure described in Example 30, (S)-5-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-2-((S)-3-methyl-2-oxo-piperazin-1-yl)-5-oxo-pentanoic acid methyl ester (intermediate 29) with 3 eq. of 4-methylmorpholine and 1.2 eq. of 2-chloro-4-isocyanato-1-trifluoromethoxy-benzene (intermediate 17) gave the titled compound in 67% yield as white foam. MS: 605.20 (MH+, Cl).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b27024efdc0741e89b527f17994e032d
来源数据集: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08445674B2
来源说明: uspto-grants-2013_05

反应 SMILES

[CH3:1][O:2][C:3](=[O:26])[C@@H:4]([N:18]1[CH2:23][CH2:22][NH:21][C@@H:20]([CH3:24])[C:19]1=[O:25])[CH2:5][CH2:6][C:7]([N:9]1[CH2:16][CH2:15][C:12]2([CH2:14][CH2:13]2)[C@H:11]([OH:17])[CH2:10]1)=[O:8].CN1CCOCC1.[Cl:34][C:35]1[CH:40]=[C:39]([N:41]=[C:42]=[O:43])[CH:38]=[CH:37][C:36]=1[O:44][C:45]([F:48])([F:47])[F:46]>>[CH3:1][O:2][C:3](=[O:26])[C@@H:4]([N:18]1[CH2:23][CH2:22][N:21]([C:42](=[O:43])[NH:41][C:39]2[CH:38]=[CH:37][C:36]([O:44][C:45]([F:47])([F:48])[F:46])=[C:35]([Cl:34])[CH:40]=2)[C@@H:20]([CH3:24])[C:19]1=[O:25])[CH2:5][CH2:6][C:7]([N:9]1[CH2:16][CH2:15][C:12]2([CH2:14][CH2:13]2)[C@H:11]([OH:17])[CH2:10]1)=[O:8]