HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium borohydride → 3-[(3-Chloro-4-trifluoromethyl-phenyl)-(2-hydroxy-ethyl)-amino]-propionic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium borohydride | HCID 4148881 | — |
| Reactant | 3-[(3-Chloro-4-trifluoromethyl-phenyl)-methoxycarbonylmethyl-amino]-propionic acid tert-butyl ester | HCID 67074349 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-[(3-Chloro-4-trifluoromethyl-phenyl)-(2-hydroxy-ethyl)-amino]-propionic acid tert-butyl ester | HCID 67074459 | 84% |
Reaction Steps
In analogy to the procedure described for intermediate 40C, 3-[(3-chloro-4-trifluoromethyl-phenyl)-methoxycarbonylmethyl-amino]-propionic acid tert-butyl ester and LiBH4 (2 M in THF)/MeOH gave the title compound in 84% yield as yellow oil. MS: 368.12 (MH+, Cl).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08445674B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-f4e4db2592fb4b78b9f2ecafbf045661 |
| Source note | uspto-grants-2013_05 |