Tetrahydrofuran → HCID 58158578, compound

HRID 2095821Notes

Reaction equation

HRID 2095821 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[C:13](=[O:14])[C:12]([C:15]([O:17]CC)=[O:16])=[CH:11][N:10]1[CH3:20].O1CCCC1.[OH-].[Na+]>CO>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[C:13](=[O:14])[C:12]([C:15]([OH:17])=[O:16])=[CH:11][N:10]1[CH3:20]

Participants

5

Reactant 3

HCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 58158582HCID 58158582, compound

Product 1

HCID 58158578HCID 58158578, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In the same manner as in Reference Example 65 and using ethyl 2-(2-methoxyphenyl)-1-methyl-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate (2.5 g, 9.2 mmol), tetrahydrofuran (6 mL), methanol (5 mL) and 4N aqueous sodium hydroxide solution (8 mL) as starting materials, the title compound (1.9 g, 85%) was obtained as a white solid.

Sources & evidence

ORD record
ord-65938a6333cb4834afa403644b5df115
Source dataset
uspto-grants-2013_05
Patent number
US08445509B2

Reaction notes

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