Tetrahydrofuran → HCID 58158507, compound

HRID 2095824Notes

Reaction equation

HRID 2095824 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[N:9]1[C:13](=[O:14])[C:12]([C:15]([O:17]CC)=[O:16])=[CH:11][N:10]1[CH3:20].O1CCCC1.[OH-].[Na+]>CO>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[N:9]1[C:13](=[O:14])[C:12]([C:15]([OH:17])=[O:16])=[CH:11][N:10]1[CH3:20]

Participants

5

Reactant 3

HCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 58158458HCID 58158458, compound

Product 1

HCID 58158507HCID 58158507, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In the same manner as in Reference Example 65 and using ethyl 2-(2,6-dichlorophenyl)-1-methyl-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate (3.4 g, 11 mmol), tetrahydrofuran (6 mL), methanol (5 mL) and 4N aqueous sodium hydroxide solution (8 mL) as starting materials, the title compound (2.8 g, 90%) was obtained as a white solid.

Sources & evidence

ORD record
ord-f5f1cfbc5bc247e28ecd9a92cfa77877
Source dataset
uspto-grants-2013_05
Patent number
US08445509B2

Reaction notes

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