反应详情

温度

120 °C

To a solution of 5-bromo-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile (200 mg, 0.651 mmol) in N,N-dimethylformamide (2 mL) were added tetramethyltin (582 mg, 3.255 mmol) and tetrakistriphenylphosphinepalladium(0) (22.3 mg, 0.019 mmol), and the mixture was stirred at 120° C. for 17 hr. Water and ethyl acetate were added to the reaction mixture, and the mixture was extracted 3 times with ethyl acetate. The organic layer was washed with saturated brine, and the solvent was evaporated under reduced pressure. The obtained residue was washed with diethyl ether and collected by filtration to give the title compound (94 mg, 60%) as a white solid.

1. extractionthe mixture was extracted 3 times with ethyl acetate
2. washThe organic layer was washed with saturated brine
3. customthe solvent was evaporated under reduced pressure
4. washThe obtained residue was washed with diethyl ether
5. filtrationcollected by filtration