Water → HCID 58158518, compound

HRID 2095874Notes

Reaction equation

HRID 2095874 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:13]([CH3:14])=[CH:12][CH:11]=[C:10]([C:15]#N)[C:9]1=[O:17].[OH2:18].S(=O)(=O)(O)[OH:20]>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:13]([CH3:14])=[CH:12][CH:11]=[C:10]([C:15]([OH:20])=[O:18])[C:9]1=[O:17]

Participants

4

Reactant 3

HCID 962WaterHCID 1118Sulfuric AcidHCID 66968848HCID 66968848, compound

Product 1

HCID 58158518HCID 58158518, compoundYield 72%

Procedure

An aqueous solution (98% sulfuric acid 3 mL, water 3 mL) of 1-(2-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile (660 mg, 3.08 mmol) in sulfuric acid was stirred at 130° C. for 6 hr. The reaction solution was cooled to room temperature, water was added, and the precipitated solid was collected by filtration. The obtained solid was washed with ethyl acetate to give the title compound (550 mg, 72%) as a brown solid.

Workup

  1. filtrationthe precipitated solid was collected by filtration
  2. washThe obtained solid was washed with ethyl acetate

Sources & evidence

ORD record
ord-1a3676910aca4a30b72bf89db5167e6d
Source dataset
uspto-grants-2013_05
Patent number
US08445509B2

Reaction notes

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