Water → HCID 58158518, compound

Participants

Reaction Steps

An aqueous solution (98% sulfuric acid 3 mL, water 3 mL) of 1-(2-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile (660 mg, 3.08 mmol) in sulfuric acid was stirred at 130° C. for 6 hr. The reaction solution was cooled to room temperature, water was added, and the precipitated solid was collected by filtration. The obtained solid was washed with ethyl acetate to give the title compound (550 mg, 72%) as a brown solid.

Provenance & Evidence